Weed and Ayahuasca: 5 Ways They Pull You Apart (2025)

Cannabis and Ayahuasca – Two Pulls in Opposite Directions

One of the most consumed plants (after coffee and tobacco) is cannabis. It helps people relax, deal with the stress of life, and express creativity. So it’s a common topic that comes up around Ayahuasca preparation – how long they need to abstain from cannabis, what the potential risks are, what to do when they cannot stop smoking, and in general, the relationship between these two plants.

I have extensive experience with both, having been a daily smoker for 6 years and also being on the path of Ayahuasca, building a Harmonica Retreat for 4+ years now. This article comes from that lived experience.

Key takeaways: Ayahuasca and Cannabis

  • Ayahuasca brings things to the surface; cannabis numbs. Their workings are the opposite.

 

  • Ideally, you stop 2 weeks before drinking Ayahuasca, especially if you are a regular, daily smoker.

 

  • A combination of psychiatric conditions, cannabis, and Ayahuasca can be dangerous

Table of Contents

Frequently Asked Questions: Ayahuasca Soul Healing

How long before Ayahuasca should I stop smoking weed?

Ideally two weeks, especially if you are a regular, daily smoker. The longer, the better. Yet, if you are a daily smoker, the difficulty arises that it is not that easy to stop. In the end, the sooner the better, but at the very least, don’t smoke on the day of the Ayahuasca ceremony and start to decrease the amount you are smoking. Try your best to abstain for 3 – 7 days.

This is more common than one realizes. We work with the approach: do your best. You might not feel the full effects of the Ayahuasca (though you still might), but it will still help.

You have to at least not smoke on the day of the ceremony. Ideally, you don’t smoke 3 – 14 days before your encounter with Ayahuasca. Other traditions usually have more strict approaches.

It depends on who you ask and each situation has to be looked at individually. There are multiple aspects that need to be taken into consideration: if you have certain psychiatric conditions, your emotional stability, your willingness to heal, your past experiences with “psychedelics” etc.

What we have observed is that the effects of the Ayahuasca are usually numbed. It usually doesn’t fully activate if people cannot stop smoking 3-7 days before the ceremony, yet there are still benefits the person receives from the ceremony.

Kambo or other purgatives can help clean the body and make you more receptive to the medicine

Important Considerations

How potent is the Ayahuasca you are drinking?

With Peruvian Ayahuasca, you probably need to stop 4-6 weeks before the ceremony. Colombian Ayahuasca is generally considered more potent, so 1-2 weeks is generally enough to connect well with the medicine.

How regularly do you smoke?

The more you smoke, the sooner you should stop (or be okay with feeling the effects less, and it’s recommended to do a purge before Ayahuasca).

Are you okay with feeling the effects less?

Be aware of your self-sabotage. Maybe you are saying, “Oh, if I cannot stop smoking, I shouldn’t drink.” And this might also be a way of procrastination, of not wanting to face the underlying fear. Here it goes back to: we do the best we can, and we receive what we are supposed to receive in the moment we participate in a ceremony.

Understanding How They Work—The Opposite Ways

The way Ayahuasca works is that it shines a light. It brings the unconscious to the conscious. On the contrary, cannabis tends to bury emotions—it numbs us down, especially when used a lot. So their mechanisms are contrary. It is good to give space between these plants so each one can develop without the interference of the other.

The Shamanic View of Cannabis – A Power Plant

Cannabis allows us to amplify our intention, whether it is to relax, to connect, or to be creative—it can help us dive deeper into our intention.

The elders say that cannabis is also a “Diva,” a plant that will start playing with your attention. And if you do not approach the plant with a firmness in your intention, it will start to take “control” over you.

There are very, very few people that I know who actually use cannabis consciously.

The Shamanic View of Ayahuasca – A Master Plant

Ayahuasca is considered by the elders as a master plant. In a way, it knows us better than we know ourselves. It will give us what we need, in the intensity that we need it, when we connect with it.

Sometimes we believe we need an answer for topic A in our life, but Ayahuasca might show us a different route, things that we have maybe even overlooked for years. Or it helps us resolve the topic we came with, in ways that we didn’t expect.

It is a true master plant that also requires a lot of dedication and discipline when working with it.

Understanding the Risks – This Is Important

This section is crucial, and I want to be very clear about it because safety comes first.

The Risk of Psychosis

The combination of Ayahuasca, cannabis, and certain psychiatric conditions—especially schizophrenia or a family history of schizophrenia—can be dangerous.

Here’s what you need to understand: cannabis alone, when combined with a predisposition to schizophrenia, already carries significant risk. It can trigger psychotic episodes in vulnerable individuals. When you add Ayahuasca into the mix, you’re combining two powerful psychoactive substances, and this can dramatically increase the risk of triggering a psychotic break.

In this blog we dive deeper into the topic of “Can Ayahuasca cause Psychosis”. 

Who Should Not Participate

If you have:

  • A personal history of schizophrenia or psychosis
  • A family history of schizophrenia (parents, siblings)
  • A diagnosis of bipolar disorder or other serious psychiatric conditions
  • Been told by a mental health professional that you’re at risk for psychosis

You need to have a serious conversation with both a mental health professional and the facilitators before considering Ayahuasca. In many cases, it may simply not be safe for you to participate, especially if you’re also a regular cannabis user with serious psychiatric conditions.

You can find more detailed information about this topic in our blog: Who should not drink Ayahausca 

ayahuasca retreat harmonica altar

Find out if Ayahuasca is right for you

  • Will you be safe physically and emotionally?
  • How will you be supported in the ceremony?
  • How do the facilitators handle difficult situations?
  • How will you be able to process the experience?
  • You want change, but will your life be unrecognizable after Ayahuasca?

+ 13 things to consider before drinking Ayahuasca?

Personal Observations From Years of Experience

  • I have seen regular cannabis smokers who couldn’t stop smoking still have powerful ceremonies.
  • I have seen people who are regular cannabis smokers have lesser effects from the Ayahuasca.
  • Other factors need to be taken into consideration: is the person using other drugs, are they on other medications, their emotional state and willingness to heal.
  • Purging the body is especially beneficial when one is a regular smoker and approaching Ayahuasca. More about Ayahuasca and Purgatives here
  • If people don’t stop their unhealthy weed habit after Ayahuasca, the long-term benefits of the Ayahuasca are minimized. Smoking often stops or slows down the person from taking healthy actions they should be taking to improve their lives. In this blog you can find more about the long term effects of Ayahuasca
  • I understand the difficulty of stopping smoking. My approach is: do the best you can. Start slowing down with the quantity that you are smoking. Start sitting with the uncomfortable emotions that start to come up. That in and of itself is difficult. The more you can do it, the better. More about it on our blog Ayahuasca Integration
  • Think about the reasons you want to drink Ayahuasca, your Ayahuasca Intention.  This can help serve as a “why”—a reason to cut down on the amount of weed you smoke.
  • Don’t be too hard on yourself. We are all doing the best we can.

Conclusion

The relationship between cannabis and Ayahuasca is complex, and there’s no one-size-fits-all answer. What I’ve learned through my own journey and working with others is this: these plants work in fundamentally different ways, and respecting that difference is important.

Cannabis can be a beautiful medicine when used consciously and with intention. But for many of us—myself included—it became a habit, a way to avoid feeling what we needed to feel. Ayahuasca does the opposite work. It asks us to feel everything, to face what we’ve been running from.

If you’re a regular smoker considering Ayahuasca, the medicine is already working on you. The fact that you’re reading this, asking these questions, means something inside you is ready for change. The challenge of stopping or reducing your cannabis use before ceremony is actually part of the healing process. It’s teaching you that you can sit with discomfort, that you can feel your feelings without numbing them.

Do your best. That’s all any of us can do. If you can stop two weeks before, great. If you can only manage a few days, that’s okay too. What matters most is your intention, your honesty with yourself and the facilitators, and your willingness to receive whatever healing comes your way.

But please—and I cannot stress this enough—if you have a history of psychiatric conditions, especially schizophrenia or psychosis, or if you have close family members who do, take the risk section seriously. Talk to professionals. Some journeys aren’t meant to be taken, and there’s wisdom in knowing your limits.

Trust the process. Trust yourself. And remember: the medicine gives us what we need, not always what we want, and that’s exactly as it should be.

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